¡Provides an overview of the current status of Alzheimerfs disease with additional emphasis on other related neurodegenerative disorders
¡Examines molecular conformational changes in mechanisms of neurodegenerative disease
¡Discusses current small molecule and immunological approaches to Alzheimerfs therapeutics
¡Offers a preview of forthcoming clinical studies and therapeutics
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimerfs disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimerfs Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
¡The basis of AD and the role of AÀ oligomers in development of disease
¡Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
¡In vivo imaging diagnostic approaches
¡Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
¡Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of AÀ, tau, and emerging neuroprotective/neurorepair approaches
¡How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
¡The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
¡The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Audience: Clinical neurologists, researchers in neuroscience, primary care practitioners, pharmaceutical industry professionals, healthcare service providers, and health policy makers.
¡The Amyloid À-Protein and Alzheimerfs Disease.
¡Emerging Principles and Biomarkers in In Vitro Diagnostics for Alzheimerfs Disease.
¡Imaging Biomarkers for Diagnosis, Prognosis, and Treatment of Alzheimerfs Disease.
¡The Current Status of Alzheimerfs Disease Treatment: Why We Need Better Therapies and How We Will Develop Them.
¡New Small Molecule Drug Discovery for Alzheimerfs Disease.
¡Alzheimerfs Disease: Clinical Aspects.
¡Pathogenic Protein Strains as Diagnostic and Therapeutic Targets in Alzheimerfs Disease.
¡Traumatic Brain Injury in the Development of Alzheimerfs Disease: Risk Factors, Diagnosis, and Treatment Strategies.