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Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates
Edición/Edição: 1st Autores:Paul M. Selzer Editorial:Wiley ISBN: 9783527323272 Formato: Tapa Dura/Hardback Nº volumenes: 1 Páginas: 450 Año publicación/Ano de publicação: 2009 Disponibilidad/Disponibilidade: 15 días Precio/Preço
:206,64 €(214,91€ iva incluído)
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
Editor Preface Preamble Drug Discovery: Learning to Relate Structural Space with Property Space Target Based Drug Discovery in the Animal Health Industry A Combined Bioinformatics and Molecular Biological Approach Toward the Gap Closure within a Bacterial Contig Genome Veterinary Drug Candidate Generation in the Genomic Era: Tailor Made Approaches. Optimization of NADH-Fumarate Oxidoreductase Inhibitors by Application of Conformational by Application of Conformational Analysis and Physicochemical Property Prediction Searching New Anti-Parasitics in the Virtual Space Crosslinking Bioinformatics and Chemoinformatics within Drug Discovery Total Synthesis and Configurational Assignment of Pasteurestin A and B, a Natural Product with Antimicrobial Acitivty on Pasteurella Information - The Essence of Drug Discovery From Scientific Data to Knowledge Lessons Learned from Target Based Screening in Antiinfective and Antiparasitic Research The Invertebrate Cholinergic System: Molecular Targets for Antiparasitic Compounds Phenotypic Characterization of Lead Candidates Derived from in Vitro Anti-Ectoparasitic and Anthelmintic Bioscreens for the Identification of New Antiparasitic Leads Recruiting the Host Defense Mechanisms; Roles for Chemotherapeutics and Vaccines Virulence Factors in Infectious Diseases Mode of Action of the Anthelmintic Emodepside Emergence of Resistance in Helminths New Chemotherapeutic Strategies for Schistosomiasis Kinases of Protozoan Parasites as Drug Targets Targeting the Malaria Kinome; Discovering Kinase Inhibitors as Novel Anti-Malarial Agents Unique Drug Targets in Parasites In search of Trypanocidal Drugs Target Validation of Proteases in Parasitic Protozoa Target Identification and Mechanism-Based Screening for Anthelmintics: Application of Veterinary Antiparasitic Research Programmes to Search for New Antiparasitic Drugs for Human Indications Drug Discovery for Neglected Diseases: View of a Public-Private Partnership Tuberculosis