New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.
Preface; Part I. History and General Issues: 1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology and Pathobiology: 4. Immunophenotyping Fred G. Behm; 5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 6. Cytogenetics of acute leukemias Susana C. Raimondi; 7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; 8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing; 9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero; 10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters; 11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans; 13. Acute lymphoblastic leukemia Ching-Hon Pui; 14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu; 16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; 17. Relapsed acute myeloid leukemia Ursula Creutzig; 18. Myelodysplastic syndromes Henrik Hasle; 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock; 21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman; 22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher; 23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; 24. Antibody-targeted therapy Alan S. Wayne; 25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop; 26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner; 27. Development therapeutics Sima Jeha; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious complications Hana Hakim and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Doralina L. Anghelescu and Roland Kaddoum; 35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull; 36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard; Index.