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Hematology 7th Ed. Basic Principles and Practice
Hematology 7th Ed. Basic Principles and Practice
Edición/Edição: 7th
Autores: Ronald Hoffman; Edward J. Benz, Jr.; Leslie E. Silberstein; Helen Heslop; Jeffrey Weitz; John Anastasi
ISBN: 9780323357623
Formato: Rústica/Paperback
Nº volumenes: 1 Páginas: 2200
Año publicación/Ano de publicação: 2017
Disponibilidad/Disponibilidade: 15 días
Precio/Preço : 303,99 € 300,34 € (288,79€ + iva)
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Cómpralos juntos y ahorra
Hematology 7th Ed. Basic Principles and Practice Cirugía en Coagulopatías Congénitas. Enfoque Multidisciplinario
· Hematology 7th Ed. Basic Principles and Practice (Ronald Hoffman; Edward J. Benz, Jr.; Leslie E. Silberstein; Helen Heslop; Jeffrey Weitz; John Anastasi)
· Cirugía en Coagulopatías Congénitas. Enfoque Multidisciplinario (E. Carlos Rodriguez-Merchán | V. Jiménez-Yuste)
352,07 € 334,47 €
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

New to this Edition
◾Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.
◾Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.
◾Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
◾New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.
◾Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Table of Contents
1.Anatomy and Physiology of the Gene
2.Epigenetics and Epigenomics
3.Genomic Approaches to Hematology
4.Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism
5.Protein Synthesis, Processing, and Trafficking
6.Protein Architecture: Relationship of Form and Function
7.Signaling Transduction and Metabolomics
8.Pharmacogenomics and Hematologic Diseases
9.Hematopoietic Stem Cell Biology
10.Stem Cell Model of Hematologic Malignancies
11.Hematopoietic Microenvironment
12.Cell Adhesion
13.Hematopoietic Cell Trafficking and Chemokines
14.Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
15.Vascular Growth in Health and Disease
16.Cytokine/Receptor families and signal transduction
17.Control of Cell Division
18.Cell Death
19.Overview and Compartmentalization of the Immune System
20.B-Cell Development
21.T-Cell Immunity
22.Natural Killer Cell Immunity
23.Dendritic Cell Biology
24.Complement and Immunoglobulin biology leading to clinical translation
25.Tolerance and Autoimmunity
26.Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
27.Granulocytopiesis and Monocytopoiesis
29.Inherited Forms of Bone Marrow Failure
30.Aplastic Anemia
31.Paroxysmal Nocturnal Hemoglobinuria
32.Acquired Disorders of Unilineage Blood Cell Production
33.Pathobiology of the Human Erythrocyte and Its Hemoglobins
34.Approach to Anemia in the Adult and Child
35.Pathophysiology of Iron Homeostasis
36.Disorders of Iron Metabolism: Iron Deficiency and Overload
37.Anemia of Chronic Diseases
38.Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
39.Megaloblastic Anemias
40.Thalassemia Syndromes
41.Pathobiology of Sickle Cell Disease
42.Sickle Cell Disease: Clinical Features and Management
43.Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
44.Red Blood Cell Enzymopathies
45.Red Blood Cell Membrane Disorders
46.Autoimmune Hemolytic Anemia
47.Extrinsic Nonimmune Hemolytic Anemias
48.Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia
49.Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
50.Disorders of Phagocyte Function
51.Congenital Disorders of Lymphocyte Function
52.Histiocytic Disorders
53.Lysosomal Storage Diseases: Perspectives and Principles
54.Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
55.Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
56.The CytoGenomic Basis of Hematological Malignancies
57.Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
58.Pathobiology of Acute Myeloid Leukemia
59.Clinical Manifestations and Treatment of Acute Myeloid Leukemia
60.Myelodysplastic Syndromes: Biology and Treatment
61.Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
62.Acute Myeloid Leukemia in Children
63.Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children
64.Pathobiology of Acute Lymphoblastic Leukemia
65.Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia
66.Acute Lymphocytic Leukemia in Adults
67.Chronic Myeloid Leukemia
68.The Polycythemias
69.Essential Thrombocythemia
70.Primary Myelofibrosis
71.Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
72.Mast Cells and Systemic Mastocytosis
73.The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
74.Origins of Hodgkin Disease
75.Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy
76.Origins of Non-Hodgkin Lymphomas
77.Chronic Lymphocytic Leukemia
78.Hairy Cell Leukemia
79.Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
80.Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
81.Mantle Cell Lymphoma
82.Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)
83.Viral-Related Lymphomas
84.Malignant Lymphomas in Childhood
85.T-Cell Lymphomas
86.Multiple Myeloma
87.Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma
88.Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)
89.Clinical Approach to Infections in the Compromised Host
90.Psychosocial Aspects of Hematologic Disorders
91.Pain Management and Antiemetic Therapy in Hematologic Disorders
92.Palliative Care
93.Late Complications of Hematologic Diseases and Their Therapies
94.Overview and Historical Perspective of Current Cell-Based Therapies
95.Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization
96.IND Enabling Processes for Cell-Based Therapies
97.Graft Engineering and Cell Processing
98.Principles of Cell-Based Genetic Therapies
99.Mesenchymal Stromal Cells
100.T Cell Therapy of Hematological Diseases
101.NK Cell-Based Therapies
102.Immune Checkpoint Blockade in Hematologic Malignancies
103.Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation
104.Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
105.Unrelated Donor Hematopoietic Cell Transplantation
106.Haploidentical Hematopoietic Cell Transplantation
107.Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies
108.Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy
109.Complications after Hematopoietic Cell Transplantation
110.Human Blood Group Antigens and Antibodies
111.Principles of Red Blood Cell Transfusion
112.Clinical Considerations in Platelet Transfusion Therapy
113.Human Leukocyte Antigen and Human Neutrophil Antigen Systems
114.Principles of Neutrophil (Granulocyte) Transfusions
115.Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
116.Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
117.Transfusion Therapy for Coagulation Factor Deficiencies
119.Transfusion Reactions to Blood and Cell Therapy Products
120.Transfusion-Transmitted Diseases
121.Pediatric Transfusion Medicine
122.Overview of Hemostasis and Thrombosis
123.The Blood Vessel Wall
124.Megakaryocyte and Platelet Structure
125.Molecular Basis of Platelet Function
126.Molecular Basis of Blood Coagulation
127.Regulatory Mechanisms in Hemostasis
128.Clinical Approach to the Patient with Bleeding or Bruising
129.Laboratory Evaluation of Hemostatic and Thrombotic Disorders
130.Acquired Disorders of Platelet Function
131.Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
132.Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution
133.Heparin-Induced Thrombocytopenia
134.Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
135.Hemophilia A and B
136.Inhibitors in Hemophilia A and B
137.Rare Coagulation Factor Deficiencies
138.Structure, Biology, and Genetics of Von Willebrand Factor
139.Disseminated Intravascular Coagulation
140.Hypercoagulable States
141.The Antiphospholipid Syndrome
142.Venous Thromboembolism
143.Mechanical Interventions in Arterial and Venous Thrombosis
146.Acute Coronary Syndromes
147.Atrial Fibrillation
148.Peripheral Artery Disease
149.Antithrombotic Drugs
150.Disorders of Coagulation in the Neonate
151.Hematologic Changes of Pregnancy
152.Hematologic Manifestations of Childhood Illness
153.Hematologic Manifestations of Systemic Disease: Liver Disease
154.Hematologic Manifestations of Systemic Disease: Renal Disease
155.Hematologic Manifestations of Cancer
156.Integrated Therapies in Patients with Hematologic Diseases
157.Hematologic Manifestations of AIDS
158.Hematologic Manifestations of Parasitic Diseases
159.Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
160.The Spleen and Its Disorders
161.Hematology in Aging


Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations

Author Information

By Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York ; Edward J. Benz, Jr., MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts; Leslie E. Silberstein, MD, Professor of Pathology (Pediatrics), Director, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts; Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas; Jeffrey Weitz, MD, Professor of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Heart and Stroke Foundation/J.F. Mustard Chair in Cardiovascular Research Canada Research Chair (Tier 1) in Thrombosis, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada and John Anastasi, MD, Associate Professor; Assistant Director, Hematopathology; Medical Director, Flow Cytometry; Department of Pathology, The University of Chicago; Chicago, Illinois
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