Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein's Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.
An ideal balance of the basic science you need to know and how to apply that information to clinical practice.
An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.
Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.
New to this Edition
New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.
New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.
More schematic diagrams clearly summarize information and facilitate understanding.
1 Biology of the Normal Joint
3 Cartilage and Chondrocytes
4 Biology, Physiology, and Morphology of Bone
5 Muscle: Anatomy, Physiology, and Biochemistry
7 Tissue Engineering
8 Proteinases and Matrix Degradation
9 Dendritic Cells
12 T Lymphocytes
13 B Cells
14 Fibroblasts and Fibroblast-like Synoviocytes
15 Mast Cells
16 Platelets and Rheumatic Diseases
17 Innate Immunity
18 ADAPTIVE IMMUNITY and Organization of Lymphoid Tissues
20 METABOLIC REGULATION IN IMMUNITY
21 Genetics of Rheumatic Diseases
22 Epigenetics of rheumatic diseases
23 Complement System
24 Prostaglandins, Leukotrienes, and Related Compounds
25 Cell Recruitment and Angiogenesis
27 PRINCIPLES OF SIGNALING
28 Cell Survival and Death in Rheumatic Diseases
29 Animal Models of Rheumatic Diseases
30 Neural regulation of Pain and Inflammation
31 RESEARCH METHODS IN THE RHEUMATIC DISEASES
32 BURDEN OF THE RHEUMATIC DISEASE
33 Assessment of Health Outcomes IN RHEUMATIC DISEASES
34 Biologic Markers
35 Occupational and Recreational MSK Disorders
36 Cardiovascular Risk in Rheumatic Disease
37 Cancer Risk in Rheumatic Diseases
38 Introduction to Physical Medicine, Physical Therapy and Rehabilitation
39 Pregnancy and Rheumatic Diseases
40 History and Physical Examination of the Musculoskeletal System
41 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Monoarticular Arthritis
42 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Polyarticular Arthritis
43 The Skin and Rheumatic Diseases
44 The Eye and Rheumatic Diseases
45 Neck Pain
46 Shoulder Pain
47 Low Back Pain
48 Hip and Knee Pain
49 Ankle and Foot Pain
50 Hand and Wrist Pain
51 Temporomandibular Joint Pain
53 Synovial Fluid Analysis, Synovial Biopsy, and Synovial Pathology