The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target. ◾ Fully comprehensive: covers molecular changes in a wide range of human cancers, how these are analysed, and molecular therapeutic approaches ◾ Demonstrates how basic research informs clinical practice and pharmacologic developments ◾ High-quality team of editors and contributors recruited from some of the leading cancer centers worldwide
Table of Contents
Section 1. Analytical Techniques: Analysis of DNA; Section 2. Analytical Techniques: Analysis of RNA;
Part IV . Pharmacologic Targeting of Oncogenic Pathways;
Edward P. Gelmann, Columbia University, New York Edward P. Gelmann is Chief of the Division of Hematology/Oncology and Deputy Director for Clinical Research at the Herbert Irving Comprehensive Cancer Center and Columbia University Medical Center, New York, NY, USA.
Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, New York Charles L. Sawyers is Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Frank J. Rauscher III, The Wistar Institute Cancer Centre, Philadelphia Frank J. Rauscher III is Professor of the Gene Expression and Regulation Program, Professor of the Tumor Microenvironment and Metastasis Program, and Deputy Director for Basic Research at the Wistar Institute Cancer Center, Philadelphia, PA, USA.