Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders.
Diagnosis, treatment and management of a condition are discussed in a single chapter, giving readers all of the relevant information in one place
Each chapter is written by a leading expert in the field and a wealth of clinical experience is shared with the reader
Color illustrations accompany the text to aid understanding
Table of Contents
Part I. Overview of Myeloma:
1. Epidemiology of myeloma Eve Roman and Alexandra G. Smith
2. Diagnosis and immunophenotyping of myeloma Roger Owen
3. Imaging of myeloma Nicola Mulholland and Ming Wan
Part II. Biological Basis for Targeted Therapies in Myeloma:
4. Cell cycle regulation and myeloma precursor cells John Quinn and Kwee L. Yong
5. The genetic and epigenetic mechanisms underlying the behaviour of myeloma Martin F. Kaiser, Kevin D. Boyd and Gareth J. Morgan
6. The myeloma bone marrow environment and survival signaling Kwee L. Yong, John Quinn and Asim Khwaja
7. Immune dysfunction in multiple myeloma Guy Pratt and Paul Moss
8. Myeloma bone disease: pathogenesis of bone destruction and therapeutic strategies Andrew Chantry and Neil Rabin
9. Principles of pathway directed therapy for myeloma Yu-Tzu Tai and Kenneth C. Anderson
Part III. Myeloma: Clinical Entities:
10. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma Efstathios Kastritis and Meletios A. Dimopoulos
11. Multiple myeloma: management of de novo disease T. Guglielmelli, P. Sonneveld, A. Broyl and Antonio Palumbo
12. Treatment of relapsed/refractory myeloma Matthew J. Streetly, Jacob Laubach, Paul Richardson and Stephen A. Schey
13. Solitary bone and extramedullary plasmacytoma Shirley D'Sa
14. Amyloidosis Ashutosh D. Wechalekar, Simon W. Dubrey and Raymond L. Comenzo
15. Waldenstrom's macroglobulinemia/lymphoplasmocytic lymphoma Steven P. Treon and Giampaolo Merlini
16. Castleman's disease Karthik Ramasamy
17. POEMS syndrome and paraproteinaemic syndromes: management and follow-up Angela Dispenzieri and Suzanne R. Hayman
Part IV. Supportive Therapies:
18. Treatment of emergent peripheral neuropathy and plasma cell disorders Charise Gleason, Melanie Watson and Sagar Lonial
19. Management of renal failure in multiple myeloma Aneel Paulus, Pooja Advani, Nabeel Aslam and Asher Alban Chanan-Khan
20. The management of infection in myeloma Christopher P. Conlon
Stephen A. Schey, Department of Haematology, King’s College Hospital, London
Stephen A. Schey is Professor of Plasma Cell Dyscrasias, King's College London, and a Consultant Haematologist at King's College Hospital NHS Foundation Trust, London, UK.
Kwee L. Yong, Department of Haematology, University College Hospital, London
Kwee L. Yong is Professor of Clinical Haematology, University College London, and a Consultant Haematologist at University College London Hospitals, London, UK.
Robert Marcus, Department of Haematology, King’s College Hospital, London
Robert Marcus is a Consultant Haematologist at King's College Hospital NHS Foundation Trust, London, UK.
Kenneth C. Anderson, Dana-Farber Cancer Institute, Boston
Kenneth C. Anderson is Kraft Family Professor of Medicine, Harvard Medical School, and Medical Director, Kraft Family Blood Donor Center, Dana-Faber Cancer Institute, Boston, MA, USA.