Basic Neurochemistry. Principles Of Molecular, Cellular, And Medical Neurobiology

98,12 €
Donald L. Price, R. Wayne Albers, George J. Siegel, Scott T. Brady
Academic Press
Fecha Publicacion
8 mar. 2011
DESCRIPTION This is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists. KEY FEATURES ¡Includes clinical perspective boxes in each chapter that make connections between molecular processes and disease states, between biochemistry and drug discovery enabling students to better understand neurological diseases ¡Presents cutting-edge advances in neuroscience in context of principles of brain chemistry and biology ¡Companion Web site features animations to illustrate critical biochemical processes READERSHIP advanced undergraduates, graduate students and post-docs in neuroscience or biomedical science, medical students, clinical neuroscientists and neurologists TABLE OF CONTENTS ¡Part I: Cellular Neurochemistry and Neural Membranes ¡Neuronal Cell Biology ¡Cell Membrane Structures and Functions ¡Membrane Transport ¡Electrical Excitability and Ion Channels ¡Lipids ¡The Cytoskeleton of Neurons and Glia ¡Intracellular Trafficking ¡Axonal Transport ¡Cell Adhesion Molecules ¡Myelin Structure and Biochemistry ¡Energy Metabolism of the Brain ¡PART II: Intercellular Signaling ¡Synaptic Transmission and Cellular Signaling: An Overview ¡Acetylcholine ¡Catecholamines ¡Serotonin ¡Histamine ¡Glutamate ¡GABA ¡Purinergic Systems ¡Peptides ¡PART III: Intracellular Signaling ¡G Proteins ¡Cyclic Nucleotides in the Nervous System ¡Phosphoinositides ¡Calcium ¡Serine and Threonine Phosphorylation ¡Tyrosine Phosphorylation ¡Transcription Factors in the Central Nervous System ¡PART IV: Growth, Development and Differentiation ¡Development ¡Growth Factors ¡Stem Cells in the Nervous System ¡Formation and maintenance of myelin ¡Axonal Growth in the Adult Mammalian Nervous System ¡PART V: Cell Injury and Inflammation ¡Neuroimmunology ¡Neuroinflammation ¡Hypoxic'Ischemic Brain Injury and Oxidative Stress ¡Lipid Mediators: Eicosanoids, Docosanoids, Platelet-Activating Factor and Inflammation ¡Apoptosis and Necrosis ¡PART VI: Inherited and Neurodegenerative Diseases ¡Peripheral Neuropathy ¡Diseases Involving Myelin ¡The Epilepsies: Phenotype and Mechanisms ¡Genetics of Neurodegenerative Diseases ¡Disorders of Amino Acid Metabolism ¡Diseases of Carbohydrate, Fatty Acid and Mitochondrial Metabolism, including Lysosomal and Peroxisomal Diseases ¡Disorders of Muscle Excitability ¡Motor Neuron Diseases ¡Neurobiology of Alzheimer's Disease ¡Neurodegenerative alpha-Synucleinopathies and Tauopathies ¡Trinucleotide repeat diseases ¡Neurotransmitters and Disorders of the Basal Ganglia ¡Molecular Basis of Prion Diseases ¡PART VII: Sensory Transduction ¡Molecular Biology of Vision ¡Molecular Biology of Olfaction and Taste ¡Molecular Biology of Hearing and Balance ¡Pain ¡PART VIII: Neural Processing and Behavior ¡Endocrine Effects on the Brain and Their Relationship to Behavior ¡Learning and Memory ¡Sleep ¡The Neurochemistry of Schizophrenia ¡Autism ¡Neurobiology of Severe Mood and Anxiety Disorders ¡Addiction AUTHOR Edited by George Siegel, Loyola University, Chicago, IL, USA; R. Wayne Albers, National Institutes of Health, Bethesda MD, USA and Donald Price, The Johns Hopkins University School of Medicine, Baltimore MD; Scott Brady, University of Illinois, Chicago IL
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