Comprehensive Analysis Of Parasite Biology. From Metabolism To Drug Discovery

154,72 €
Paul M. Selzer
Fecha Publicacion
30 ago. 2016
This most recent volume in the series on Drug Discovery in Infectious Diseases focusses on the use of metabolic analysis of protozoic parasites for rational drug discovery design.  Covering all classes of parasites, this ready reference covers such methodologies as virtual compound, high throughput, and cellular screening, as well as computer-assisted and structure-based drug design, and pathway modelling. Furthermore, several chapters focus on the latest technologies increasingly being used to dissect metabolic pathways and cellular processes, while enzymatic drug targets for which structural, knock out and inhibitor data are available are also included as well as recent antiparasitic agents targeting particular pathways serving as lead compounds for further drug development. With its real-life success stories, this is a must-have for all professionals dealing with drug discovery in parasitology. Contents List of Contributors IX Foreword XIX Preface XXIII Part One Identification and Validation of New Drugs and Targets 1 1 Discovery of theMechanism of Action of Novel Compounds That Target Unicellular Eukaryotic Parasites 3 Daniela Begolo∗ and Christine Clayton 2 Antiparasitics fromAlgae 41 Stefan Ringgeler and Barbara Kappes∗ 3 Contribution of Natural Products to Drug Discovery in Tropical Diseases 75 Frederick Annang, Olga Genilloud∗, and Francisca Vicente 4 Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites 105 Tina Weber and Paul M. Selzer∗ 5 Trypanosomal Cysteine Peptidases: Target Validation and Drug Design Strategies 121 Elany Barbosa da Silva, Glaécia Aparecida do Nascimento Pereira, and Rafaela Salgado Ferreira∗ 6 Potential of Pyrimidine Metabolism for Antitrypanosomal Drug Discovery 147 María Valente, Antonio E. Vidal, and Dolores González Pacanowska∗ 7 Phosphatidylcholine and Phosphatidylethanolamine Biosynthesis Pathways in Plasmodium 171 Ewelina Guca, Alicia Contet, Henri J. Vial, KaiWengelnik, and Rachel Cerdan∗ 8 Immunophilins as Possible Drug Targets in Apicomplexan Parasites 193 Alessandra Bianchin∗, Anthony J. Chubb, and Angus Bell 9 Targeting the Atg8 Conjugation Pathway for Novel Anti-Apicomplexan Drug Discovery 213 Alexia S. Miller and Jürgen Bosch∗ 10 Turnover of Glycosomes in Trypanosomes – Perspectives for Drug Discovery 231 Ana Brennand, Eva Rico, Melisa Gualdrón-López, and Paul A.M. Michels∗ 11 Glideosome of Apicomplexans as a Drug Target 255 Lauren E. Boucher and Jürgen Bosch∗ 12 N-Myristoyltransferase as a Target for Drug Discovery in Malaria 275 James A. Brannigan and Anthony J. Wilkinson∗ Part Two Metabolomics in Drug and Target Discovery 295 13 Methods to InvestigateMetabolic Systems in Trypanosoma 297 Maria Fatarova, Florian Bellvert, Edern Cahoreau, Frédéric Bringaud, and Jean-Charles Portais∗ 14 The Role of Metabolomics in Antiparasitic Drug Discovery 321 Carlo R. Giannangelo, Katherine M. Ellis, Anna E. Sexton, Daniel Stoessel, and Darren J. Creek∗ 15 The Importance of Targeting Lipid Metabolism in Parasites for Drug Discovery 343 Simon A. Young, Matthew D. Roberts, and Terry K. Smith∗ 16 CarbonMetabolism of Plasmodium falciparum 371 Marco Biddau and Sylke Müller∗ Part Three Gene Expression and Its Regulation – A Promising Research Area for Drug Discovery 399 17 Epigenetic Gene Regulation: Key to Development and Survival of Malaria Parasites 401 Sabine Anne-Kristin Fraschka and Richárd Bártfai∗ 18 Mechanisms Regulating Transcription in Plasmodium falciparum as Targets for Novel Antimalarial Drugs 421 Evelien M. Bunnik and Karine G. Le Roch∗ 19 Aminoacyl t-RNA Synthetases as Antimalarial Drug Targets 441 Anmol Chandele∗ and Amit Sharma Part Four Mathematical Approaches to Drug and Target Discovery 455 20 MathematicalModeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical Targets 457 Partho Sen, Henri J. Vial, and Ovidiu Radulescu∗ 21 Understanding Protozoan Parasite Metabolism and Identifying Drug Targets through Constraint-Based Modeling 487 Francis Isidore Totanes, Sanu Shameer, David R.Westhead, Fabien Jourdan, and Glenn A. McConkey∗ 22 Attacking Blood-Borne Parasites with Mathematics 513 David D. van Niekerk, Gerald Penkler, François du Toit, Jacky L. Snoep, Barbara M. Bakker, and Jurgen R. Haanstra∗ Index 543
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