Hippocampal Microcircuits · A Computational Modeler's Resource Book

282,79 € 271,91 €
Cutsuridis, Vassilis, Graham, Bruce, Cobb, Stuart, Vida, Imre
Fecha Publicacion
1 ene. 2010
About this book

The hippocampus is amongst the most widely studied of mammalian brain regions (see The Hippocampus Book, Eds. P. Andersen, R. Morris, D. Amaral, T. Bliss, J. O’Keefe. Oxford University Press, 2007) and is hypothesized to play a role in the short-term storage of declarative memories. Recent years have witnessed a dramatic accumulation of knowledge about the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus.

Microcircuits can be thought of as functional modules that act as elementary processing units bridging the gap between single cell activity, network activity and global brain function. Microcircuits can be found in many parts of mammalian nervous systems and consist of a complex architecture involving many different neuronal types connected in feed forward and feedback loops.

Synaptic connections may be excitatory or inhibitory and target specific spatial locations on a neuron. In addition to synaptic input, a neuron and the microcircuit it is a part of are subject to diffuse neuromodulatory signals. Neural synaptic transmission and neuromodulation combine to provide a complex dynamics of neural activity and presumed information processing in a neuronal microcircuit.

The book is divided into two thematic areas: (1) Experimental background and (2) Computational analysis. In the first thematic area, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus.

This engaging volume will be invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields will find this book a significant source of information.

This volume will act as a self-contained source book for computational neuroscientists developing hippocampal models. It will be invaluable entirely in itself, but will also form a useful companion volume to The Hippocampus Book (OUP, 2007.)

Written for:
Computational neuroscientists, experimental neuroscientists

Table of contents
Preface.-Biographical Data on Contributors.-Introduction.-Experimental Background.-Connectivity of the Hippocampus: Intraareal Connectivity: CA1, CA3, DG. Intrareal Connectivity.-Topography of Inputs: EC, Subiculum.-Cell Morphologies: Pyramidal Cells. Granule Cells.-Interneurons.-Physiological Properties of Neurons: Passive Membrane Properties. Active Properties: Ion Channel Distributions. Synaptic Properties: Distribution and Characteristics of Glutamatergic Inputs. Distribution and Characteristics of GABAergic Inputs.-Neuromodulation.-Neuronal Activity Patterns: In Vitro. In Vivo.-Awake, Behaving Animals.-Computational Analysis.-Single Neuron Models: CA1 Pyramidal Cells. CA3 Pyramidal Cells. Granule Cells.-Identified Interneurons.-EC Cells.-Identified Interneurons.-EC Cells.-Models of Network Activity: Oscillations and Behavior.-Physiology-based Models: Associative Memory, Place Cells and Spatial Navigation.-Models of Synaptic Plasticity.-Short-term Dynamics.-LTP/LTD (Including STDP).-Computer Simulation Environments for Neuron and Network Modeling.-NEURON.-GENESIS.-NeuroConstruct.-Catacomb.-Author Index.-Subject Index.
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