Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.
Professional Researchers in Mechanobiology, Tissue Engineering and Biomaterials
Overview.- The mechanobiology and biochemistry in cells subjected to sustained mechanical deformations.- Metabolic transport in chronically loaded soft tissues.- Cell death and damage thresholds in mechanically loaded tissues.- Bioengineering aspects of the microcirculation of wounds and of angiogenesis in healing wounds.- Tissue engineering models of chronic wounds.- Computational models of cellular and molecular processes in chronic wound formation.- Computer models of tissue repair and regeneration.- Biomaterials and tissue engineering approaches for wound repair.- Biomaterials in wound dressing.- Biomaterials for controlled drug delivery in wound repair.- Proteomic approaches to quantify phases of wound healing.