This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging.
According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Basic scientists who are interested in learning more about clinical epileptology, as well as clinicians who would like to understand more about fundamental mechanisms will find this text useful. Residents and postdoctoral fellows, particularly those interested in a career in epilepsy, will benefit from the continuity and organization of this single-authored comprehensive textbook.
The new edition of Seizures and Epilepsy updates an outstanding volume, initially published in 1989. Dr. Engel has been able to reduct the numerous current advances in epileptology, (i.e. genetics, imaging, molecular biology, electroencephalography, treatments) since the original publication, and make them all readily available to all practitioners interested in epilepsy. This easy to read volume is a must." -- Solomon L. Moshé, MD, President, International League Against Epilepsy, Charles Frost Chair In Neurosurgery and Neurology, Professor of Neurology, Neuroscience & Pediatrics, Vice-Chair, Dept. of Neurology, Director, Pediatric Neurology & Clinical Neurophysiology, Einstein College of Medicine, Bronx, NY
"Professor Engel has been one of the most influential world figures in epilepsy over the last 40 years. The 2nd edition of this book has thus been eagerly awaited, and it is indeed a magnificent achievement. It is a compendium of knowledge and wisdom that will surely become a standard reference for all clinicians working in the field." -- Simon Shorvon FRCP. Professor in Clinical Neurology, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square London, and Co-Editor in Chief of Epilepsia
"The Second Edition of Seizures and Epilepsy is worth the long wait. There are few figures in the epilepsy field who can match Engel for his breadth and depth of knowledge, from the basic science of cellular mechanisms to clinical manifestations of epilepsy syndromes to therapeutic treatment approaches. This new edition is significantly updated, and provides the reader with a clear understanding of how recent molecular and genetic discoveries, as well as advances in neuroimaging, have led to new clinical insights and therapeutic options. Written in Dr. Engel's unusually lucid style, and well-illustrated, Seizures and Epilepsy is a basic resource for the senior epileptologist as well as an attractively accessible introduction to the field for the curious neurologist and neuroscientist. Engel's Seizures and Epilepsy was - and is - this reader's absolute choice for 'the book' to have on epilepsy. - Philip A. Schwartzkroin, PhD, Department of Neurological Surgery,UC Davis
"That Dr. Engel is a superb lecturer and teacher is clearly reflected in this book. That was the conclusive remark in Warren's Blume's review of the first edition of Seizures and epilepsy", that appeared in the New England Journal Medicine in 1990. More than 20 years later, there are no better words to describe a reader's feelings about the second edition of the book... No other publication so beautifully reflects the author's unique insight, acquired in over 40 years of tireless work between the clinic and the research laboratory. I recommend this book to not only to all clinicians who manage people with epilepsy, but also to all scientists interested in unravelling the mechanisms and finding new treatments for a disease that affects 50 million people worldwide." -- Emilio Perucca, MD, PhD, FRCP(Edin), Clinical Pharmacology Unit, University of Pavia, Italy
About the Author
Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, and The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences at UCLA. He is past president of the American Clinical Neurophysiology Society, the American Epilepsy Society, and the International League Against Epilepsy, and is past co-chair of the Global Campaign against Epilepsy. His bibliography lists over 1,000 publications and over 30 books, and he is principal investigator on three research grants from the National Institute of Neurological Disorders and Stroke. He has received numerous awards and honors, including a Fulbright Scholarship, a Guggenheim Fellowship, and a Javits Award.