Molecular mechanisms in legionella pathogenesis (current topics in microbiology and inmunology, vol.376)

152,87 € 146,99 €
Hubert Hilbi
Fecha Publicacion
19 oct. 2013
· Written by leading authorities in the field · Provides an up-to-date and comprehensive? overview · Contributes to an in-depth-understanding of Legionnaires' disease Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila. Table of Contents From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts. Pedro Escoll, Monica Rolando, Laura Gomez-Valero and Carmen Buchrieser The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors. Gil Segal Facets of small RNA-mediated regulation in Legionella pneumophila. Hana Trigui, Nilmini Mendis, Laam Li, Mariam Saad and Sebastien P. Faucher Type II secretion and Legionella virulence. Nicholas P. Cianciotto Effector translocation by the Legionella Icm/Dot type IV secretion system. Jiazhang Qiu and Zhao-Qing Luo Modulation of small GTPases by Legionella. Roger S. Goody and Aymelt Itzen Host lipidation: A mechanism for spatial regulation of Legionella effectors. Stanimir S. Ivanov and Craig Roy Phosphoinositides and the Legionella pathogen vacuole. Ina Haneburger and Hubert Hilbi Legionella phospholipases implicated in virulence. Katja Kuhle and Antje Flieger Cytotoxic glucosyltransferases of Legionella pneumophila. Yury Belyi, Thomas Jank and Klaus Aktories Modulation of the ubiquitination machinery by Legionella. Andree Hubber, Tomoko Kubori and Hiroki Nagai Host signal transduction and protein kinases implicated in Legionella infection. Andrew D. Hempstead and Ralph R. Isberg Mouse models of Legionnaires´ disease. Andrew S Brown, Ian R van Driel and Elizabeth L Hartland
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