Pathogenesis Of Mycobacterium Tuberculosis And Its Interaction With The Host Organism (Current Topics In Microbiology And Immunology, Vol. 374)

152,87 € 146,99 €
Pieters, J. , McKinney, J.
Fecha Publicacion
1 ene. 2014
Description · A stimulus for the further exploration of the intricate biology of Mycobacterium tuberculosis and its interaction with the host · Written by respected experts from different disciplinesRichly illustrated Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts. Table of Contents Genetic Diversity in Mycobacterium tuberculosis Sebastien Gagneux DNA Metabolism in Mycobacterial Pathogenesis Digby F. Warner, Tone Tønjum and Valerie Mizrahi Molecular Biology of Drug Resistance in Mycobacterium tuberculosis Tasha Smith, Kerstin A. Wolff, and Liem Nguyen Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan Getting Across the Cell Envelope: Mycobacterial Protein Secretion Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria Giulia Manina and John D. McKinney Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes Sabine Ehrt and Kyu Rhee Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters Host-Pathogen Interactions During Mycobacterium tuberculosis Infections Sarah Stanley and Jeffery S. Cox
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