Animal Models For Human Cancer: Discovery And Development Of Novel Therapeutics

179,08 € 172,19 €
Marianne I. Martic-Kehl, P. August Schubiger
Fecha Publicacion
2 jul. 2016
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development. Contents Preface INTRODUCTION ETHICS IN ANIMAL RESEARCH Introduction Today's R&D Environment "Do no Harm" - The Essential Dilemma of Animal Research Man and Animals in Philosophy - An Overview of Key Concepts Conclusions - Solving the Dilemma STUDY DESIGN Introduction Design Principles Experimental Design Conclusion IMPROVING EXTERNAL VALIDITY OF EXPERIMENTAL ANIMAL DATA Introduction Variation in the Laboratory The Fallacies Future Perspectives: An Experimental Strategy Integrating Adaptive Plasticity and Fundamental Methodology HOW TO END SELECTIVE REPORTING IN ANIMAL RESEARCH Introduction Definition and Different Manifestations of Reporting Bias Magnitude of Reporting Biases Consequences Causes of Reporting Bias Solutions A COMPREHENSIVE OVERVIEW OF MOUSE MODELS IN ONCOLOGY Why Mouse as Models of Cancer What is a Good Mouse Model of Cancer What are the Tools for Making One Humanized Mice: Why Humanized Mice Mouse Models for Immunological Research in Oncology Applications and Limitations of Mouse Models of Cancer: Strategies and Accomplishments for Producing Complicated Models in Mouse: Other Mouse Models Potentials, Limitations, and Future Directions for Mouse Models in Oncology Drug Development: In the Time of Personalized Medicine How can we Improve them for Cancer Drug Development: With Particular Stress on the Different Phases of Drug Development MOUSE MODELS OF ADVANCED SPONTANEOUS METASTASIS FOR EXPERIMENTAL THERAPEUTICS Mouse Tumor Models in Cancer Research The Evolution of Metronomic Chemotherapy Development of Highly Aggressive and Spontaneously Metastatic Breast Cancer Models Is There any Evidence that Models of Advanced Metastatic Disease have the Potential to Improve Predicting Future Outcomes of a Given Therapy in Patients? Metronomic Chemotherapy Evaluation in Preclinical Metastasis Models Experimental Therapeutics using Metastatic Her-2 Positive Breast Cancer Xenograft Models Examples of Recently Developed Orthotpic Models of Human Cancers Factors that can Affect the Usefulness of Preclinical Models in Evaluationg New Therapies Monitoring Metastatic Disease Progression in Preclinical Models Alternative Preclinical Models - PDX and GEMMs Recommendations for the Evaluation of Anti-Cancer Drugs Using Preclinical Models Summary SPONTANEOUS TUMOR ANIMAL MODELS Introduction Advantages of Spontaneous Canine / Feline Cancer Registries Spontaneous Animal Tumors as Suitable Models for Human Cancers The Swiss Canine / Feline Cancer Registry 1955-2008 Conclusion DOG MODELS OF NATURALLY OCCURRING CANCER Introduction Advantages of Spontaneous Cancer Models in Dogs Dog Cancer Models Preclinical and Vetinary Translational Investigations in Dogs with Cancer Necessary Developments for Realizing the Potential of Canine Models Key Challenges and Recommendations for Using Canine Models Conclusions IMPROVING PRECLINICAL CANCER MODELS: LESSONS FROM HUMAN AND CANINE CLINICAL TRIALS OF METRONOMIC CHEMOTHERAPY Introduction: Low-Dose Metronomic Chemotherapy Clinical Trials of Metronomic Chemotherapy Veterinary Metronomic Trials in Pet Dogs with Cancer Lessons Learned from Clinical Trials: Improving the Predictability of Preclinical Models Conclusions Author Information Marianne Martic is a senior assistant at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of the Swiss Federal Institute of Technolgy(ETH) and the University of Zurich (UZH). She joined the institution after obtaining her degree at the radiopharmaceutical institute of ETH Zürich, where she has worked on animal experimental protocols in the field of positron emission tomography (PET). Her current research is focused on the systematic reviewing and meta-analysis of preclinical animal experiments. August Schubiger is a senior fellow at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of ETH and UZH. He has been full Professor ofRadiopharmacy at the Institute of Pharmaceutical Sciences at ETH Zurich and headed the Center for Radiopharmaceutical Science of the ETH, the Paul ScherrerInstitute (PSI) and at the Clinic and Polyclinic for Nuclear Medicine at the UZH until 2010. He is currently involved in the project 'Drug development - significance and predictive value of animal testing'.
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