Management Of Urologic Cancer: Focal Therapy And Tissue Preservation

136,32 € 131,08 €
Disponible
ISBN
9781118864623
Edición
Autores
Mark Schoenberg, Kara L. Watts
Editorial
Wiley
Fecha Publicacion
2 ago. 2017
Características
N/D
Managing urologic cancer by preserving, as opposed to removing, affected tissue, is rapidly becoming the favoured choice for urologists and oncologists. Discover all available options and how to achieve the best possible patient management with this expert guide to the area. The editor, Mark Schoenberg, is an internationally-renown expert in this exciting new area and has recruited an outstanding team featuring some of the leading urologists/oncologists in North America and Europe to assist him. Table of Contents List of Contributors xiii Preface xvii Cancer Genetics, Cancer Biology, and Tumor Growth and Metastasis: The Interaction of Cancer and Its Host Environment 1 Mark C. Markowski and Kenneth J. Pienta Renal Cell Carcinoma 1 Bladder Cancer 3 Prostate Cancer 6 References 12 Pathological Basis of Tumor Characterization: Cytopathology, Surgical Pathology, and How Histo ]Morphology Informs Treatment Decision Making 19 Oleksandr N. Kryvenko and Fadi Brimo The Kidney 23 The Urothelium 27 The Testis 29 References 30 The Immunobiology of Tumor Ablation 33 Rafi Kabarriti and Chandan Guha Manipulating the Immune System to Fight Cancer 33 Can We Take Advantage of Ablative Therapies to Activate the Immune System? 34 Immunomodulatory Properties of HIFU 35 Immunomodulatory Properties of Cryotherapy 36 Immunomodulatory Properties of Radiation Therapy 37 References 38 Computed Tomography of Urologic Malignancies: The Role of MDCT in Renal Cell Carcinoma and Transitional Cell Carcinoma 41 Siva P. Raman and Elliot K. Fishman Introduction 41 MDCT Protocol Design 41 Three ]Dimensional Reconstructions 44 Neoplasms of the Intrarenal Collecting Systems, Ureters, and Bladder 45 Solid Renal Parenchymal Lesions 49 Conclusion 55 References 55 MRI and Metabolic Imaging 59 Louise Dickinson, Francesco Fraioli, Athar Haroon, and Clare Allen Magnetic Resonance Imaging 59 MRI Sequences 59 Clinical Applications of MRI for Prostate Cancer 61 Clinical Applications of MRI for Renal Cancer 63 Clinical Applications of MRI for Bladder Cancer 64 New Advances in MRI 65 Metabolic Imaging 66 Clinical Applications of PET–CT for Prostate Cancer 69 Active Surveillance for Low ]Risk Prostate Cancer 113 Laurence Klotz Introduction and Background 113 Rationale 113 Genetic Features of Low ]Grade Prostate Cancer 114 Metastatic Potential 115 Limitations of PSA Kinetics 116 Role of MRI 116 Implications for Patient Management 117 Eligibility for Surveillance 118 Outcome of Surveillance 119 Modeling 119 AS in Practice 121 Conclusions 121 References 122 Tissue ]Preserving Surgical Approaches in Urologic Oncology: The Therapeutic Mechanism for Tumor Ablation 127 Ganesh Kartha and J. Stephen Jones Introduction 127 Cryoablation: Extreme Cold for Tumor Necrosis 128 Conclusion 130 References 130 Focal Therapy for Prostate Cancer: An Evidence ]Based Approach to Tissue ]Preserving Strategies 133 Kara L. Watts, Yaalini Shanmugabavan, Victoria Chernyak, and Hashim Uddin Ahmed Introduction 133 Key Concepts in FT for PCa 134 Tissue ]Preserving FTs 135 Cryotherapy 135 HIFU 137 Salvage Focal/Hemiablation HIFU 140 IRE 141 Radiation 142 Additional Therapies 143 Implications for Research 144 Conclusions 144 References 145 The Modern Basis for Nephron ]Sparing Surgery in Patients with Renal Cancer: Biologic Heterogeneity, the Significance of Tumor Biopsy, and the Changing Roles of Partial Nephrectomy and Tumor Ablation 151 Jeffrey J. Tomaszewski, Robert G. Uzzo, and David Y.T. Chen Introduction 151 Principal Treatment Options for SRMs and the Basis for Nephron Preservation 152 Comparative Effectiveness of Radical versus NSS 153 Rationale for Ablative Therapies 154 Treatment Trends for Stage I RCC 157 The Role of RMB 158 Challenges Posed by Intratumoral Heterogeneity 161 Conclusions 161 References 162 Bladder ]Preserving Strategies in the Treatment of Urothelial Cancer: The Disease Spectrum and the Dawn of Molecular Surgical Guidance 169 Stephan Kruck and Arnulf Stenzl Augmented Cystoscopy 170 Fiber ]Optic Probe Technology 171 Conclusion 172 References 172 Image ]Guided Thermal Ablation of Adrenal Malignancies 175 Kyungmouk Steve Lee, Bradley B. Pua, and Stephen B. Solomon Introduction 175 Clinical Results 175 Preprocedural Evaluation 176 Technical Considerations 178 RFA 178 Microwave Ablation 179 Cryoablation 180 Complications 180 Follow ]up 181 Conclusion 182 References 182 Managing Penile Cancer: Integrating Tissue Preservation, Energy ]Based Therapeutics, and Surgical Reconstruction 185 Arthur L. Burnett Introduction 185 Description 186 Diagnosis and Staging 186 Treatment 189 References 193 Testis Cancer: Testis ]Sparing Cancer Surgery 199 Nilay M. Gandhi and Pravin K. Rao Introduction 199 Imaging of Testicular Tumors 199 Bilateral Tumors 201 The Advent of Testis ]Sparing Surgery 201 Concerns about TSS 201 Indications for TSS 204 Preoperative Considerations and Surgical Technique 204 Postoperative Care and Follow ]Up 207 Considerations Regarding Surgical Technique 207 Outcomes of TSS 208 Summary 209 References 210 Nanotechnology: An Evolution in Tissue Preservation and Focal ]Targeted Oncologic Therapy 213 Kara L. Watts and Joshua M. Stern Introduction 213 Introduction to Nanotechnology 214 Types of Nanoparticles 214 Delivery and Use of Nanoparticles 217 Nanotechnology in Prostate Cancer 219 Imaging in Prostate Cancer 219 Therapeutics in Prostate Cancer 221 Nanotechnology in Renal Cancer 223 Nanotechnology in Other Urologic Cancers 224 Limitations of Nanoparticles 224 Future Directions and Conclusions 225 References 226 Trial Design Issues in the Study of Focal Therapy in Prostate and Kidney Cancer 233 John B. Eifler and David F. Penson Issues around Endpoints in Studies of Focal Therapy 234 Issues around Defining the Study Population and the Control Arms of Comparative Studies in Focal Therapy 237 Issues around Selecting the Optimal Study Design in Focal Therapy 238 Conclusion 238 References 239 Index 000 Author Information Mark Schoenberg,MD University Professor & Chair The Department of Urology The Montefiore Medical Center and The Albert Einstein College of Medicine NY, USA Kara Watts, MD Assistant Professor The Department of Urology The Montefiore Medical Center and The Albert Einstein College of Medicine NY, USA
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