Hematology 7th Ed. Basic Principles and Practice

300,34 € 288,79 €
Ronald Hoffman, Edward J. Benz, Jr., Leslie E. Silberstein, Helen Heslop, Jeffrey Weitz, John Anastasi
Elsevier Internacional
Fecha Publicacion
1 sept. 2017
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. New to this Edition ◾Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. ◾Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. ◾Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. ◾New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. ◾Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices. Table of Contents 1.Anatomy and Physiology of the Gene 2.Epigenetics and Epigenomics 3.Genomic Approaches to Hematology 4.Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism 5.Protein Synthesis, Processing, and Trafficking 6.Protein Architecture: Relationship of Form and Function 7.Signaling Transduction and Metabolomics 8.Pharmacogenomics and Hematologic Diseases 9.Hematopoietic Stem Cell Biology 10.Stem Cell Model of Hematologic Malignancies 11.Hematopoietic Microenvironment 12.Cell Adhesion 13.Hematopoietic Cell Trafficking and Chemokines 14.Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization 15.Vascular Growth in Health and Disease 16.Cytokine/Receptor families and signal transduction 17.Control of Cell Division 18.Cell Death 19.Overview and Compartmentalization of the Immune System 20.B-Cell Development 21.T-Cell Immunity 22.Natural Killer Cell Immunity 23.Dendritic Cell Biology 24.Complement and Immunoglobulin biology leading to clinical translation 25.Tolerance and Autoimmunity 26.Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 27.Granulocytopiesis and Monocytopoiesis 28.Thrombocytopoiesis 29.Inherited Forms of Bone Marrow Failure 30.Aplastic Anemia 31.Paroxysmal Nocturnal Hemoglobinuria 32.Acquired Disorders of Unilineage Blood Cell Production 33.Pathobiology of the Human Erythrocyte and Its Hemoglobins 34.Approach to Anemia in the Adult and Child 35.Pathophysiology of Iron Homeostasis 36.Disorders of Iron Metabolism: Iron Deficiency and Overload 37.Anemia of Chronic Diseases 38.Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 39.Megaloblastic Anemias 40.Thalassemia Syndromes 41.Pathobiology of Sickle Cell Disease 42.Sickle Cell Disease: Clinical Features and Management 43.Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 44.Red Blood Cell Enzymopathies 45.Red Blood Cell Membrane Disorders 46.Autoimmune Hemolytic Anemia 47.Extrinsic Nonimmune Hemolytic Anemias 48.Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia 49.Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia 50.Disorders of Phagocyte Function 51.Congenital Disorders of Lymphocyte Function 52.Histiocytic Disorders 53.Lysosomal Storage Diseases: Perspectives and Principles 54.Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases 55.Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications 56.The CytoGenomic Basis of Hematological Malignancies 57.Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies 58.Pathobiology of Acute Myeloid Leukemia 59.Clinical Manifestations and Treatment of Acute Myeloid Leukemia 60.Myelodysplastic Syndromes: Biology and Treatment 61.Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults 62.Acute Myeloid Leukemia in Children 63.Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children 64.Pathobiology of Acute Lymphoblastic Leukemia 65.Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia 66.Acute Lymphocytic Leukemia in Adults 67.Chronic Myeloid Leukemia 68.The Polycythemias 69.Essential Thrombocythemia 70.Primary Myelofibrosis 71.Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes 72.Mast Cells and Systemic Mastocytosis 73.The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas 74.Origins of Hodgkin Disease 75.Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy 76.Origins of Non-Hodgkin Lymphomas 77.Chronic Lymphocytic Leukemia 78.Hairy Cell Leukemia 79.Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal) 80.Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma 81.Mantle Cell Lymphoma 82.Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL) 83.Viral-Related Lymphomas 84.Malignant Lymphomas in Childhood 85.T-Cell Lymphomas 86.Multiple Myeloma 87.Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma 88.Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis) 89.Clinical Approach to Infections in the Compromised Host 90.Psychosocial Aspects of Hematologic Disorders 91.Pain Management and Antiemetic Therapy in Hematologic Disorders 92.Palliative Care 93.Late Complications of Hematologic Diseases and Their Therapies 94.Overview and Historical Perspective of Current Cell-Based Therapies 95.Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization 96.IND Enabling Processes for Cell-Based Therapies 97.Graft Engineering and Cell Processing 98.Principles of Cell-Based Genetic Therapies 99.Mesenchymal Stromal Cells 100.T Cell Therapy of Hematological Diseases 101.NK Cell-Based Therapies 102.Immune Checkpoint Blockade in Hematologic Malignancies 103.Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation 104.Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults 105.Unrelated Donor Hematopoietic Cell Transplantation 106.Haploidentical Hematopoietic Cell Transplantation 107.Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies 108.Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy 109.Complications after Hematopoietic Cell Transplantation 110.Human Blood Group Antigens and Antibodies 111.Principles of Red Blood Cell Transfusion 112.Clinical Considerations in Platelet Transfusion Therapy 113.Human Leukocyte Antigen and Human Neutrophil Antigen Systems 114.Principles of Neutrophil (Granulocyte) Transfusions 115.Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins 116.Preparation of Plasma-Derived and Recombinant Human Plasma Proteins 117.Transfusion Therapy for Coagulation Factor Deficiencies 118.Hemapheresis 119.Transfusion Reactions to Blood and Cell Therapy Products 120.Transfusion-Transmitted Diseases 121.Pediatric Transfusion Medicine 122.Overview of Hemostasis and Thrombosis 123.The Blood Vessel Wall 124.Megakaryocyte and Platelet Structure 125.Molecular Basis of Platelet Function 126.Molecular Basis of Blood Coagulation 127.Regulatory Mechanisms in Hemostasis 128.Clinical Approach to the Patient with Bleeding or Bruising 129.Laboratory Evaluation of Hemostatic and Thrombotic Disorders 130.Acquired Disorders of Platelet Function 131.Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 132.Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution 133.Heparin-Induced Thrombocytopenia 134.Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes 135.Hemophilia A and B 136.Inhibitors in Hemophilia A and B 137.Rare Coagulation Factor Deficiencies 138.Structure, Biology, and Genetics of Von Willebrand Factor 139.Disseminated Intravascular Coagulation 140.Hypercoagulable States 141.The Antiphospholipid Syndrome 142.Venous Thromboembolism 143.Mechanical Interventions in Arterial and Venous Thrombosis 144.Atherothrombosis 145.Stroke 146.Acute Coronary Syndromes 147.Atrial Fibrillation 148.Peripheral Artery Disease 149.Antithrombotic Drugs 150.Disorders of Coagulation in the Neonate 151.Hematologic Changes of Pregnancy 152.Hematologic Manifestations of Childhood Illness 153.Hematologic Manifestations of Systemic Disease: Liver Disease 154.Hematologic Manifestations of Systemic Disease: Renal Disease 155.Hematologic Manifestations of Cancer 156.Integrated Therapies in Patients with Hematologic Diseases 157.Hematologic Manifestations of AIDS 158.Hematologic Manifestations of Parasitic Diseases 159.Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 160.The Spleen and Its Disorders 161.Hematology in Aging APPENDIX: Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations Author Information By Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York ; Edward J. Benz, Jr., MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts; Leslie E. Silberstein, MD, Professor of Pathology (Pediatrics), Director, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts; Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas; Jeffrey Weitz, MD, Professor of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Heart and Stroke Foundation/J.F. Mustard Chair in Cardiovascular Research Canada Research Chair (Tier 1) in Thrombosis, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada and John Anastasi, MD, Associate Professor; Assistant Director, Hematopathology; Medical Director, Flow Cytometry; Department of Pathology, The University of Chicago; Chicago, Illinois
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