Immune Dysfunction and Immunotherapy in Heart Disease

170,35 € 163,80 €
Disponible
ISBN
9781405155687
Edición
1st
Autores
Douglas Larson, Ronald Ross Watson
Editorial
Blackwell Publishing
Fecha Publicacion
15 sept. 2007
Características
N/D

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.

The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address:

  • Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes
  • Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs
  • Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs
  • Immune Dysfunction Leading to Heart Disease: Induction by Pathogens

Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

PART 1: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes
01 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling
02 Immune Mechanisms In Pediatric Cardiovascular Disease
03 Heart failure - role of autoimmunity
04 Immune basis of Hypertension in Humans
05 Immune Dysregulation: Potential Mediator of Metabolic Syndrome-Induced Cardiac Remodeling
06 T-Helper 2 Cell Cytokines In Remodelling Of Aortic Wall
07 Effects of TNF-alpha on Cardiac Function
08 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy
09 Immunotherapy for left ventricular dysfunction after heart transplantation

PART 2: Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs
10 Immunmodulating therapy in chronic heart failure
11 Statins in Atherosclerosis: Role of Immune Regulation
12 ACE Inhibitors as Immunmodulators: Treatment of Cardiovascular Disease
13 Treatment of Heart Failure by Anticytokine Therapies

PART 3: Immune Dysfunction Leading to Heart Dysfunction: Induction or prevention by Cardiotherapeutic Drugs
14 Pathogenesis Of Cardiovascular Complications In The Acquired Immunodeficiency Syndrome
15 Cytokines and T cell-Mediated Responses in Autoimmune Myocarditis
16 Drugs of abuse: Accentuation of immunomodulation of viral myocarditis

PART 4: Immune Dysfunction Leading to Heart Disease: Induction by Pathogens
17 Osteopontin: The link between the Immune System and cardiac remodeling
18 Inflammatory immune activation in heart failure patients; Therapeutic implications
19 Role of Innate Immune Dysregulation in Diabetic Heart Failure
20 Tolerance in Heart Transplantation: Current and Future Role
21 Neutralization of Th2 cytokines in therapy of cardiovascular pathology
22 Anti-inflammatory immune therapy in heart disease
23 Cholesterol Synthesis, Interleukin 6 inflammation and Atherosclerosis - Role of statins, bisphosphonates and plant polyphenols in Atherosclerosis and other diseases of Aging
24 Autoimmune myocarditis. Treatment with anti-T-cell antibodies
25 Immunosuppressive Therapy To Counter Cardiac Allograft Vasculopathy
26 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling
27 Role of oral pathogens in the pathogenesis of coronary heart disease
28 Myocardial regenerative potential by stem cell transplant
29 Bioflavanoids and Dietary Anti-Inflammatory Actions: Role in Cardiovascular Diseases

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