The Neuregulin-I/ErbB Signaling System in Development and Disease

127,75 € 122,84 €
Disponible
ISBN
9783540371052
Edición
XI
Autores
Britsch, Stefan
Editorial
Springer
Fecha Publicacion
1 ene. 2007
Características
N/D
About this book

Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase receptors of the ErbB family. this signailing system has a wide range of functions during development of the nervous system, the heart, and the mammary gland. Furthermore, Neuregulin signals are also involved in the development of human diseases including breast cancer, heart disease and the pathogenesis of schizophrenia.

Written for:
Scientists and researchers in the fields of Cellular and Developmental Biology
Keywords:
CNS development
ErbB receptors
Schwann cells
Sox 10/ErbB connection
nural crest cells


Table of contents

Introduction – Molecular control of development.- Biology of the Neuregulin/ErbB signaling network.- Neuregulins and their receptors.- Developmental functions of the Neuregulin-1/ErbB signalling pathway.- Interacting molecules – the Sox10/ErbB connection.- NRG-1/ErbB signals and disease.- Abbreviations.- References.- Subject index

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