Elevate patient care with hematology expertise
Unlock essential insights to ensure optimal patient outcomes with Hematology: Basic Principles and Practice, 7th Edition. This comprehensive text is fully updated with unmatched scientific insights and critical clinical guidance, designed to enhance your diagnostic and therapeutic skills in this rapidly evolving discipline.
What’s new in this edition
- Provides cutting-edge information and advice from world-class editors and contributors leading their fields.
- Offers extensive updates across the text, incorporating foundational basic science research, innovations in stem cell transplantation, advancements in treatment for various hematologic cancers, immune checkpoint therapies, molecular diagnostics, transfusion medicine, and much more.
- Introduces several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
- Features a new Virtual Microscope that allows users to zoom in on high-resolution digital hematopathology slides, always accessible through your preferred digital device.
- Includes the Expert Consult™ eBook version with your purchase, allowing text, figures, Q&As, and references to be searched across multiple devices.
Table of contents
- Anatomy and physiology of the gene
- Epigenetics and epigenomics
- Genomic approaches to hematology
- Regulation of gene expression, transcription, splicing, and RNA metabolism
- Protein synthesis, processing, and trafficking
- Protein architecture: Relationship of form and function
- Signaling transduction and metabolomics
- Pharmacogenomics and hematologic diseases
- Hematopoietic stem cell biology
- Stem cell model of hematologic malignancies
- Hematopoietic microenvironment
- Cell adhesion
- Hematopoietic cell trafficking and chemokines
- Interactions between hematopoietic stem and progenitor cells and the bone marrow
- Vascular growth in health and disease
- Cytokine/receptor families and signal transduction
- Control of cell division
- Cell death
- Overview and compartmentalization of the immune system
- B-cell development
- T-cell immunity
- Natural killer cell immunity
- Dendritic cell biology
- Complement and immunoglobulin biology
- Tolerance and autoimmunity
- Biology of erythropoiesis and erythroid differentiation
- Granulocytopiesis and monocytopoiesis
- Thrombocytopoiesis
- Inherited forms of bone marrow failure
- Aplastic anemia
- Paroxysmal nocturnal hemoglobinuria
- Acquired disorders of unilineage blood cell production
- Pathobiology of the human erythrocyte and its hemoglobins
- Approach to anemia in adults and children
- Pathophysiology of iron homeostasis
- Disorders of iron metabolism
- Anemia of chronic diseases
- Heme biosynthesis and its disorders
- Megaloblastic anemias
- Thalassemia syndromes
- Pathobiology of sickle cell disease
- Sickle cell disease: Clinical features and management
- Hemoglobin variants associated with hemolytic anemia
- Red blood cell enzymopathies
- Red blood cell membrane disorders
- Autoimmune hemolytic anemia
- Extrinsic nonimmune hemolytic anemias
- Granulocytosis, granulocytopenia, monocytosis, and monocytopenia
- Lymphocytosis, lymphocytopenia, hypergammaglobulinemia, and hypogammaglobulinemia
- Disorders of phagocyte function
- Congenital disorders of lymphocyte function
- Histiocytic disorders
- Lysosomal storage diseases
- Infectious mononucleosis and other diseases
- Progress in classification of hematopoietic and lymphoid neoplasms
- The cyto genomic basis of hematological malignancies
- Pharmacology of antineoplastic agents
- Pathobiology of acute myeloid leukemia
- Clinical manifestations and treatment of AML
- Myelodysplastic syndromes
- Allogeneic hematopoietic stem cell transplantation
- Acute myeloid leukemia in children
- Myelodysplastic and myeloproliferative syndromes in children
- Pathobiology of acute lymphoblastic leukemia
- Clinical manifestations and treatment in children of acute lymphoblastic leukemia
- Acute lymphocytic leukemia in adults
- Chronic myeloid leukemia
- The polycythemias
- Essential thrombocythemia
- Primary myelofibrosis
- Eosinophilia and associated diseases
- Mast cells and systemic mastocytosis
- Classification of non-Hodgkin and Hodgkin lymphomas
- Origins of Hodgkin disease
- Hodgkin lymphoma: Clinical manifestations, staging, and therapy
- Origins of non-Hodgkin lymphomas
- Chronic lymphocytic leukemia
- Hairy cell leukemia
- Clinical manifestations and treatment of indolent lymphomas
- Clinical manifestations, staging, and treatment of follicular lymphoma
- Mantle cell lymphoma
- Diagnosis and treatment of diffuse large B-cell lymphoma
- Viral-related lymphomas
- Malignant lymphomas in childhood
- T-cell lymphomas
- Multiple myeloma
- Waldenstrom macroglobulinemia
- Immunoglobulin light-chain amyloidosis
- Clinical approach to infections in the compromised host
- Psycho-social aspects of hematologic disorders
- Pain management in hematologic disorders
- Palliative care
- Late complications of hematologic diseases
- Overview of current cell-based therapies
- Practical aspects of hematologic stem cell harvesting
- IND enabling processes for cell-based therapies
- Graft engineering and processing
- Principles of gene therapies
- Mesenchymal stromal cells
- T cell therapy of hematological diseases
- NK cell-based therapies
- Immune checkpoint blockade in hematologic malignancies
- Overview and choice of donor for transplantation
- Indications and outcomes for allogeneic hematopoietic cell transplantation
- Unrelated donor hematopoietic cell transplantation
- Haploidentical hematopoietic cell transplantation
- Unrelated donor cord blood transplantation
- Graft-versus-host disease and its therapy
- Complications after hematopoietic cell transplantation
- Human blood group antigens and antibodies
- Principles of red blood cell transfusion
- Clinical considerations in platelet transfusion therapy
- Human leukocyte antigen systems
- Principles of neutrophil transfusions
- Transfusion of plasma derivatives
- Preparation of plasma-derived proteins
- Transfusion therapy for coagulation deficiencies
- Hemapheresis
- Transfusion reactions
- Transfusion-transmitted diseases
- Pediatric transfusion medicine
- Overview of hemostasis and thrombosis
- The blood vessel wall
- Megakaryocyte and platelet structure
- Molecular basis of platelet function
- Molecular basis of blood coagulation
- Regulatory mechanisms in hemostasis
- Clinical approach to bleeding or bruising
- Laboratory evaluation of disorders
- Acquired disorders of platelet function
- Diseases of platelet number
- Thrombocytopenia causes
- Heparin-induced thrombocytopenia
- Thrombotic thrombocytopenic purpura
- Hemophilia A and B
- Inhibitors in hemophilia
- Rare coagulation factor deficiencies
- Structure and genetics of von Willebrand factor
- Disseminated intravascular coagulation
- Hypercoagulable states
- The antiphospholipid syndrome
- Venous thromboembolism
- Mechanical interventions in thrombosis
- Atherothrombosis
- Stroke
- Acute coronary syndromes
- Atrial fibrillation
- Peripheral artery disease
- Antithrombotic drugs
- Coagulation disorders in neonates
- Hematologic changes in pregnancy
- Hematologic manifestations of childhood illness
- Hematologic manifestations of systemic disease
- Hematologic problems in surgery
- The spleen and its disorders
- Hematology in aging
Appendix
Resources for the hematologist including interpretive comments and selected reference values for neonates, pediatrics, and adults.
Author Information
By Ronald Hoffman, MD, and esteemed contributors across various institutions.