Description
Janeway鈥檚 Immunobiology serves as a foundational textbook that explores the immune system in its entirety, catering to undergraduate students while also offering comprehensive insights beneficial for graduate students engaged in research and medical students oriented towards clinical applications. The eighth edition has undergone extensive revisions and updates, making it available in both print and e-book formats.
This edition of Janeway鈥檚 Immunobiology continues to maintain its reputation for relevance and expertise, characterized by its clear narrative, structured organization, consistent artistic presentation, and scientific precision. The text maintains a unified perspective on the interaction between the host and various potentially harmful microorganisms. Additionally, the extensive color art program coherently illustrates the mechanisms and processes outlined in the text. Comprising 16 chapters, this accessible textbook is thoughtfully organized to effectively deliver a thorough one-semester course on immunology, starting with innate immunity, progressing to adaptive immunity, and concluding with applied clinical immunology.
Features of the textbook
At the end of Chapters 2 to 16, there are discussion questions that can serve as a review tool or a foundation for class discussions and informal study groups. Each section and chapter concludes with summaries. Consistent with past editions, a caduceus icon in the margins indicates topics that relate to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.
What’s new in the eighth edition
- The section on innate immunity has been updated and expanded, now presented in two separate chapters (Chapters 2 and 3), and further emphasized throughout the book. Chapter 2 encompasses antimicrobial peptides and the complement system, while Chapter 3 focuses on cellular innate receptors and cell-mediated innate immunity, like TLRs, phagocytosis, NK cells, and interferon production.
- The complement section has been restructured to begin with the lectin pathway, facilitating easier teaching by contextualizing it within innate recognition.
- Elements of evolution have been integrated throughout the textbook to enhance student understanding of universal strategies across different organisms.
- Chapter 7, focusing on Signaling Through Immune System Receptors, has been revised for a cohesive synthesis of immunological signaling, with enhancements in the representation of antigen recognition signaling and lymphocyte activation.
- The chapter addressing B-cell immune responses (Chapter 10) has received updates, particularly regarding B cell trafficking within peripheral lymphoid organs, like lymph nodes and their interactions with antigens.
- Chapter 12 on mucosal immunity has been modernized to include responses to commensal microbiota and the role of specialized dendritic cells and regulatory T cells in maintaining tolerance to food antigens and commensal bacteria.
- Chapter 13 on Failures of Host Defense Mechanisms has been reorganized and revised to facilitate a better understanding of primary immunodeficiencies concerning developmental pathways.
- Chapter 16, Manipulation of the Immune Response, has undergone significant revision, emphasizing clinical issues and providing a comprehensive update on immunotherapeutics and vaccines.
- Numerous new and revised figures visually represent the processes and mechanisms discussed in the text.
- The icons utilized have been updated and expanded, now with a fresh focus on signaling pathways.
- New references have been included throughout.
Table of Contents
Part I: An Introduction to Immunobiology and Innate Immunity
- Chapter 1: Basic Concepts in Immunology
- Chapter 2: Innate Immunity: The First Lines of Defense
- Chapter 3: The Induced Responses of Innate Immunity
Part II: The Recognition of Antigen
- Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
- Chapter 5: The Generation of Lymphocyte Antigen Receptors
- Chapter 6: Antigen Presentation to T Lymphocytes
Part III: The Development of Mature Lymphocyte Receptor Repertoires
- Chapter 7: Signaling Through Immune System Receptors
- Chapter 8: The Development and Survival of Lymphocytes
Part IV: The Adaptive Immune Response
- Chapter 9: T Cell-Mediated Immunity
- Chapter 10: The Humoral Immune Response
- Chapter 11: Dynamics of Adaptive Immunity
- Chapter 12: The Mucosal Immune System
Part V: The Immune System in Health and Disease
- Chapter 13: Failures of Host Defense Mechanisms
- Chapter 14: Allergy and Allergic Diseases
- Chapter 15: Autoimmunity and Transplantation
- Chapter 16: Manipulation of the Immune Response